1/21/2024 0 Comments Tcr sequenceMolecular basis of a dominant SARS-CoV-2 spike-derived epitope presented by HLA-A*02:01 recognised by a public TCR. SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors. Allelic variation in class I HLA determines CD8 + T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2. Rapid and stable mobilization of CD8 + T cells by SARS-CoV-2 mRNA vaccine. Quantifiable predictive features define epitope-specific T cell receptor repertoires. Identifying specificity groups in the T cell receptor repertoire. Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells. Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates. Cross-reactive and mono-reactive SARS-CoV-2 CD4 + T cells in prepandemic and COVID-19 convalescent individuals. Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants. T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity. Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning. Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant. T cell responses to SARS-CoV-2 spike cross-recognize Omicron. Effects of previous infection and vaccination on symptomatic Omicron infections. Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 + T cells. SARS-CoV-2 vaccination diversifies the CD4 + spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infection. Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. Functional responsiveness of memory T cells from COVID-19 patients. ![]() Tavukcuoglu, E., Horzum, U., Cagkan Inkaya, A., Unal, S. ![]() Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8 + and CD4 + T cells of broad specificity. Durability of booster mRNA vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 subvariants. Vaccine-induced and naturally-acquired protection against Omicron and Delta symptomatic infection and severe COVID-19 outcomes, France, December 2021 to January 2022. Protection and waning of natural and hybrid immunity to SARS-CoV-2. Synthesis of longitudinal bulk ex vivo single-chain TCRβ repertoires and paired-chain TCRɑβ sequences from droplet sequencing of T S cells provides a roadmap for the rapid assessment of T cell responses to vaccines and emerging pathogens. TCR sequence similarity clustering identified public CD8 + and CD4 + TCR motifs associated with spike (S) specificity. Vaccinations led to large expansions in memory T S cell clonotypes, most of which were CD8 + T cells, while also eliciting diverse T S cell clonotypes not observed before vaccination. To investigate the kinetics of spike-reactive T (T S) cells from SARS-CoV-2 infection through messenger RNA vaccination in persons with hybrid immunity, we identified the T cell receptor (TCR) sequences of thousands of index T S cells and tracked their frequency in bulk TCRβ repertoires sampled longitudinally from the peripheral blood of persons who had recovered from coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previous infection alone. Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8 + T cells in persons with previous COVID-19
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